Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control
نویسندگان
چکیده
منابع مشابه
Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control
Natural killer (NK) cells provide essential protection against viral infections. One of the defining features of this lymphocyte population is the expression of a wide array of variable cell surface stimulatory and inhibitory NK receptors (sNKR and iNKR, respectively). The iNKR are particularly important in terms of NK-cell education. As receptors specific for MHC class I (MHC I) molecules, the...
متن کاملKnow thyself.
This article is part of a For-Discussion-Section of Methods of Information in Medicine on "Biomedical Informatics: We Are What We Publish" written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by this editorial and followed by a commentary paper with invited comments. In their paper, P. Elkin et al. attempt to define the fields of Medical Informatics and Bioinformatics...
متن کاملKnow Thyself.
Self-knowledge has never been a central topic; in empirical psychology. There are pockets of research on self-knowledge in different subdisciplines of the field, but until now there has been little communication between them. I believe that these areas will converge in the next few years into a cohesive study of how people form judgments about their past, current, and future selves and about th...
متن کاملA subset of natural killer cells achieve self-tolerance without expressing inhibitory receptors specific for self MHC molecules Running title: NK cells lacking inhibitory receptors for self MHC
Nadine C. Fernandez*, Emmanuel Treiner*, Russell E. Vance, Amanda M. Jamieson, Suzanne Lemieux, and David H. Raulet Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley CA 94720-3200 Institut National de la Recherche Scientifique-Institut Armand Frappier, Universite du Quebec, Laval H7V 1B7, Canada *These authors contributed equally to this...
متن کاملNK cell self tolerance, responsiveness and missing self recognition.
Natural killer (NK) cells represent a first line of defense against pathogens and tumor cells. The activation of NK cells is regulated by the integration of signals deriving from activating and inhibitory receptors expressed on their surface. However, different NK cells respond differently to the same stimulus, be it target cells or agents that crosslink activating receptors. The processes that...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2014
ISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00175